COVID 19 is a viral disease caused by a virus called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The first case was identified in Wuhan, China in December 2019. The virus responsible is a RNA virus that spreads when an infected person comes in close contact with other person and the virus enters the body through the nose or mouth. The infection is a zoonotic infection means it has jumped from a non-human animal (vertebrate) to humans. 

The virus is still very new and the scientists are bust studying its behaviours and steps through which it infects a healthy host. If these steps can be elucidated, the search for the drugs targeting specifically any step of the cascade can be carried out. The main culprit is the layer of spike proteins on the fatty layer surface of the virus. The name coronavirus (corona meaning crown) is derived from these because the presence of spikes gives the virus the characteristic crown appearance. This spike protein binds to the ACE2 (Angiotensin Converting Enzyme 2) and since this receptor is ubiquitous (present on all cells), the virus can practically get internalized into any kind of cell. This is one of the reasons why the infection by this novel coronavirus has widespread ramifications, and can later have long lasting consequences. 

Once inside the cell, the virus uses its enzymes to use the replication machinery of the host and replicate its own genetic material. Then this genetic material is packed using the enzymes and proteins that the virus synthesizes, and a complete virion is produced and released. This virion has infection causing ability and can attack other healthy cells. The most effective drug, Remdesivir, exerts antiviral action by acting as a ribonucleotide analogue inhibitor of the enzyme RNA polymeraze.

The novel coronavirus has so far been shown to attack the respiratory system more than the other systems of the body. The lungs are the main targets apart from the involvement of other organs. But since the receptor through which it enters into the cells of the body, it is still very early to say to what extent the virus can cause problems and what other organs get affected and show any symptoms in the long run.

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Frequently asked questions about COVID-19 Specialist

What are the symptoms of coronavirus infection?

Coronavirus binds to an enzymatic receptor called ACE2 (Angiotensin Converting Enzyme 2) which is present in all the cells and hence its infection causes symptoms that involve many organs. The main symptoms are:

  • Fever
  • Blocked or runny nose
  • Sore throat
  • Nasal discharge dripping behind throat
  • Generalized fatigue
  • Body aches
  • Headache
  • Chills
  • Dry coughing
  • Loss of sensation of taste and smell
  • Sneezing
  • Swelling and reddening of the toes and the fingers
  • Breathing difficulties

In children, symptoms of the mysterious Kawasaki disease are also appearing due to coronavirus infection. These symptoms are:

  • Joint pain
  • Diarrhea
  • Vomiting
  • Abdominal pain
  • Fever
  • Red eyes without any discharge
  • A rash on the trunk and in the genital area
  • Cracked lips
  • An extremely red and swollen tongue
  • Red skin on the palms of the hands and the soles of the feet
  • Swollen lymph nodes in the neck
  • Irritability
  • Peeling of the skin on the hands and feet
Can coronavirus infection recur?

Although the chances are very less, it is not impossible for the coronavirus infection to strike again. The virus is a mutating one and hence its infective power can differ than the earlier attack. One should not get complacent at all after getting recovered from the infection and utmost care should be taken.

How does coronavirus spread?

Coronavirus usually spreads when it enters into the body through nose or mouth and get deposited on the mucous membranes. When an infected person speaks, salivary droplets of varying sizes are formed which can travel in the air by remaining suspended. These droplets can pack the virus and carry them for long distances where they get deposited. When a person comes in contact with the virus, it can enter the body. Therefore social distancing is one of the main preventive measures that can help to prevent the occurrence of infection. According to a study by Japanese researchers, the salivary droplets that are very small in size can travel up to almost 20 feet before settling on the ground by remaining suspended in the air for quite a long time.

What are the less common symptoms of coronavirus infection?

Since coronavirus enters the cells of humans by binding onto an enzymatic receptor called ACE2 (Angiotensin Converting Enzyme 2) which is present in all the cells, it can cause myriad of symptoms which can highly vary among individuals. The less common symptoms include:

  • Nausea and vomiting
  • Swelling and redness in the toes and fingers of legs
  • Kawasaki disease like manifestations in children
Does coronavirus affect the babies in pregnant females?

Research done till now has showed that coronavirus infection doesn’t have any detrimental effect to the growing baby in a pregnant female. But as the virus is new and very little data is available, it is impossible to come to a definite conclusion as to what are the long term effects of the infection on the developing baby.

Is it true there is another strain of coronavirus?

Coronavirus has a very high mutation rate and there may be other strains. But the pathogenicity of this new strain still remains to be established.

Does steam inhalation kill coronavirus?

People believe that steam inhalation can kill coronavirus and lot of such messages are made viral on social media. But the truth is that there are no studies to back such a claim and such advices should be taken with a pinch of salt. There are many other benefits of steam inhalation but what exactly is the effect on coronavirus, still remains to be understood.

Why is there loss of taste and smell in coronavirus infection?

Those who lose the sensation of taste and smell in coronavirus infection generally have better prognosis than those whose lungs are affected. The mechanism by which it causes such an effect is still unknown.

The infection caused by the novel coronavirus that is COVID 19 infection occurs when the virus enters the cells of the body by a receptor called ACE2 (Angiotensin Converting Enzyme 2) and since this receptor is ubiquitous (present on all cells), the virus can practically get internalized into any kind of cell. It has been observed so far that the virus attacks respiratory system the most. The lungs are affected the most. If the infection is not treated earlier, it can irreversibly damage the lungs by causing fibrosis necessitating a lung transplant. The main symptoms of the COVID 19 infection are:

  • Fever
  • Blocked or runny nose
  • Sore throat
  • Nasal discharge dripping behind throat
  • Generalized fatigue
  • Body aches
  • Headache
  • Chills
  • Dry coughing
  • Loss of sensation of taste and smell
  • Sneezing
  • Swelling and reddening of the toes and the fingers
  • Breathing difficulties

In children, symptoms of the mysterious Kawasaki disease are also appearing due to coronavirus infection. These symptoms are:

  • Joint pain
  • Diarrhea
  • Vomiting
  • Abdominal pain
  • Fever
  • Red eyes without any discharge
  • A rash on the trunk and in the genital area
  • Cracked lips
  • An extremely red and swollen tongue
  • Red skin on the palms of the hands and the soles of the feet
  • Swollen lymph nodes in the neck
  • Irritability
  • Peeling of the skin on the hands and feet

The elderly are the most affected and those with comorbid conditions are at most risk. When people with diabetes, obesity or high blood pressure contract coronavirus infection, the treatment becomes quite challenging and the outcome becomes tricky. It can also cause internal blood clots in the patients.

The management of the disease includes controlling the symptoms. Usually hydroxychloroquine along with anticoagulant is prescribed. In moderate cases that are hospitalized and are on supplemental oxygen, the course of the drug Remdesivir helps to manage the disease and has got better prognosis. In mild cases where supplemental oxygen is usually not needed, Favipiravir is prescribed to manage the disease. Paracetamol is prescribed to control fever and generalized body aches.

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