The factors that can lead to the formation of sarcomas can be the following:
Sarcomas rarely occur due to a previous injury or trauma but they can arise in scar tissue that occur due to previous operation, burn, fracture or foreign body implantation. Exposure to some of the potent chemical carcinogens may also cause the formation of sarcomas.
Iatrogenic (relating to illness caused by medical examination or treatment) factors
Sarcomas can occur in patients who have been treated with radiation therapy. The tumor mostly arises from the irradiated field.
Kapsosi sarcoma usually occurs in patients with AIDS
Congenital or acquired immunodeficiency, including therapeutic immunosuppression, increases the risk of sarcoma.
Some mutations can lead to the formation of sarcomas in certain individuals.